It is an antiseptic, astringent, diuretic, and uterine alterative. This herb is often used for both menstruating and pregnant women. The Native Americans used it in the last few weeks of pregnancy to prepare for childbirth. Squaw Vine is used for menstrual irregularities (amenorrhea, dysmenorrhea, and menorrhagia) and for vaginal discharge (antiseptic properties for vaginal infections). It is tonifying to both the uterus and ovaries and helps to relieve congestion. Other uses include: dropsy, gravel, suppression of the urine, diarrhea. It has a calming effect on the nervous system and may improve digestion. As a salve, it may be applied to sore nipples while nursing. Other external uses include as a wash for skin problems.